In Endometrial Cancers Originating from the Uterine Corpus, Does the Location of the Tumor Affect the Prognosis?

<b>Objectives:</b> This study examines the influence of the uterine wall region from which a tumor originates on the prognosis of endometrial cancers (ECs) originating from the uterine corpus without lower uterine segment involvement (LUSI). <b>Methods:</b> This study included 68 EC patients who were operated on between January 2015 and January 2022 and met the following criteria: no LUSI noted in the final pathology report; endometrioid adenocarcinoma originating from the uterine corpus, as noted in the histopathology report; and Stages 1A and 1B tumors, classified according to the FIGO 2009 staging system. From the final pathology results after the operation, these patients were divided into four groups according to the uterine wall region from which the tumor originated: the anterior wall, posterior wall, fundus, and lateral wall. <b>Results:</b> No statistically significant difference was recorded between the groups regarding age, BMI, comorbidity, nulliparity, stage, grade, tumor size, DFS, and OS (<i>p</i> > 0.05). LVSI was detected at a higher rate in the anterior and posterior wall groups than in the fundus and lateral wall groups (<i>p</i> = 0.038). Similarly, the rates of recurrence and death were statistically notably higher in the anterior and posterior wall groups in comparison with those in the other two groups (<i>p</i> < 0.001). <b>Conclusions:</b> In endometrioid adenocarcinomas of the uterine corpus, tumors originating from the anterior and posterior walls have a worse prognosis than those originating from the fundus and lateral wall. Closer follow-up may be necessary for endometrial cancers originating from the anterior and posterior uterine walls.