Design, Synthesis, Antimicrobial Activities, and Molecular Docking Studies of New Glyco‐Conjugates of Amino Acid Derivatives

Abstract The existence of MDR and XDR strains of bacteria is a serious threat to mankind. Therefore, the development of new drug molecules with different modes of action is the need of the hour. Medicinal chemists and chemical biologists around the globe are making continuous efforts to combat this challenging health issue. In this effort, we have designed and efficiently synthesized amino acid glycoconjugates of D‐glucose as new glycohybrids. These novel glyconjugates were screened against Staphylococcus aureus and Staphylococcus epidermidis Gram (+) ve and Escherichia coli Gram (−) ve bacterial strains. The antibiofilm properties of these glyconjugates were also studied. Furthermore, these compounds were evaluated for their antifungal property against two fungal strains, namely Candida albicans and Candida parapsilosis . The detailed antimicrobial activity is presented here. The molecular docking of selected active glycoconjugates is carried out with bacterial gyrase and fungal α‐demethylase and compared with standard drugs novobiocin and fluconazole, respectively, which revealed some interesting molecular interactions.