Sex as an independent risk factor for cerebellar mutism syndrome: a validation study
This study provides critical insights into the significant role of sex as an independent risk factor for Cerebellar Mutism Syndrome (CMS) following posterior fossa tumor surgeries in pediatric patients. By identifying male sex, midline tumor location, and medulloblastoma pathology as independent predictors, this research addresses a gap in understanding sex-based disparities in CMS development. These findings suggest potential gender-specific differences in cerebellar and language development, offering a foundation for future translational research and targeted clinical strategies. The results emphasize the need for heightened monitoring and tailored interventions, especially for male patients, to mitigate CMS risk and improve surgical outcomes in pediatric neurosurgery.
Authors
- Xiaojiao Peng (ORCID: https://orcid.org/0009-0004-6264-6031)
- Nijia Zhang (ORCID: https://orcid.org/0000-0002-7406-1143)
- Xinyi Chai (ORCID: https://orcid.org/0000-0003-1090-8410)
- Kaiyi Zhu (ORCID: https://orcid.org/0000-0002-0727-6996)
- Yingjie Cai (ORCID: https://orcid.org/0000-0001-9421-2001)
- Wenping Ma (ORCID: https://orcid.org/0000-0003-2624-5850)
- Ming Ge (ORCID: https://orcid.org/0000-0002-4476-4331)
- Hong Zhang (ORCID: https://orcid.org/0000-0003-4037-7497)
- Yin Guangheng
- Hailang Sun (ORCID: https://orcid.org/0009-0005-9256-9564)
- Zhuo Zhi
- Wei Yang (ORCID: https://orcid.org/0000-0003-3157-6662)
- Jia Wang (ORCID: https://orcid.org/0000-0002-2330-8505)
Institutions
- Shanxi Medical University (CN)
- Capital Medical University (CN)
- Beijing Children’s Hospital (CN)
- Shanxi Academy of Medical Sciences (CN)
Publication Details
- Journal
- Frontiers in Surgery
- Published
- 2025-09-15
- DOI
- https://doi.org/10.3389/fsurg.2025.1645832
- Primary Topic
- Vestibular and auditory disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00