Copper Chelation by Penicillamine Protects Against Doxorubicin-Induced Cardiomyopathy by Suppressing FDX1-Mediated Cuproptosis
This study provides experimental evidence implicating cuproptosis in DOX-induced cardiomyopathy. PEN exerts cardioprotection, potentially by targeting this pathway, offering a promising therapeutic strategy.
Authors
- Manar A. Didamoony (ORCID: https://orcid.org/0000-0002-6602-6815)
- Khaled S. El-Bayoumi
- Yaser Hosny Ali Elewa (ORCID: https://orcid.org/0000-0002-7347-4587)
- Amal F. Dawood (ORCID: https://orcid.org/0000-0001-7646-0909)
- Maha Alhelf (ORCID: https://orcid.org/0000-0002-8648-360X)
- Eman M. Embaby (ORCID: https://orcid.org/0000-0001-8518-7641)
- Hany M. A. Sonpol (ORCID: https://orcid.org/0000-0002-8031-3765)
- Wesam S. El-Saeed
- Mohamed A. M. Ali (ORCID: https://orcid.org/0000-0001-8217-0262)
- Mohamed Adel
- Mohammad El-Nablaway
- Eman Serry Zayed
Institutions
- Hokkaido University of Science (JP)
- Princess Nourah bint Abdulrahman University (SA)
- Cairo University (EG)
- Mansoura University (EG)
- Zagazig University (EG)
- Sapporo University (JP)
- Hokkaido University (JP)
- Imam Mohammad ibn Saud Islamic University (SA)
- University of Bisha (SA)
- Dar Al Uloom University (SA)
- Nile University (EG)
- Egyptian Russian University (EG)
- University of Tabuk (SA)
Publication Details
- Journal
- Biomolecules
- Published
- 2025-09-15
- DOI
- https://doi.org/10.3390/biom15091320
- Citations
- 4
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 5.55