A new polyketide, asperone A, isolated from the endophytic fungus <i>Aspergillus versicolor</i> JGC-G1 and its antifungal activity
ABSTRCTOne previously undescribed polyketide compound (<b>1</b>) and eight known ones (<b>2-9</b>) were isolated from the endophytic fungus <i>Aspergillus versicolor</i> JGC-G1. Their chemical structures were elucidated by HRESIMS, 1D and 2D NMR analysis, experimental ECD, and calculated ECD data. Nine polyketide compounds were assessed for antifungal activity against <i>Candida albicans</i> CMCC 98001 and <i>Aspergillus niger</i> R330. Compounds <b>1</b> and <b>7</b> showed significant antifungal effect against these two fungi, with the MICs ranging from 0.781 to 3.125 μg/ml.
Authors
- Xu-Ri Wan
- Fang Yue (ORCID: https://orcid.org/0000-0002-3258-785X)
- Lingyan Liu (ORCID: https://orcid.org/0000-0001-5268-5986)
- Xuan Lu (ORCID: https://orcid.org/0000-0001-9180-9435)
- Yihui Yang (ORCID: https://orcid.org/0000-0001-9549-4071)
- Chang Li (ORCID: https://orcid.org/0000-0001-7919-5565)
- Yue‐Hu Pei
Institutions
- Harbin Medical University (CN)
- Dalian University (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1080/10286020.2025.2558637
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00