Screening FDA-Approved Oncology Drugs with Three-Dimensional Spheroids Identifies Romidepsin as a Therapeutic Candidate for Osteosarcoma
Our unbiased sarcosphere-based drug screen identified romidepsin as a promising candidate to repurpose for human and canine patients with metastatic osteosarcoma. This screening strategy allowed us to identify romidepsin-sensitive and -resistant patients. Sarcosphere-based screening may therefore be useful to identify patients most likely to respond clinically to romidepsin or other drugs.
Authors
- Spencer M. Richardson (ORCID: https://orcid.org/0000-0002-5554-4799)
- Maegan L. Capitano (ORCID: https://orcid.org/0000-0002-5210-5221)
- M. Reza Saadatzadeh (ORCID: https://orcid.org/0000-0002-7976-7970)
- James D. Buschbach
- Gabrielle J. Knafler
- L. Daniel Wurtz (ORCID: https://orcid.org/0000-0001-6341-492X)
- Sheldon L. Padgett
- Patrick J. Getty (ORCID: https://orcid.org/0000-0002-2716-3032)
- Christopher M. Fulkerson (ORCID: https://orcid.org/0000-0003-4201-821X)
- Michael O. Childress (ORCID: https://orcid.org/0000-0001-6127-4679)
- Christopher D. Collier (ORCID: https://orcid.org/0000-0003-2639-4290)
- Edward M. Greenfield (ORCID: https://orcid.org/0000-0002-0921-983X)
- Rance M. Gamblin
- Deep A. Gandhi
- Karen E. Pollok (ORCID: https://orcid.org/0000-0001-6031-5707)
- Emily E. Seiden (ORCID: https://orcid.org/0000-0003-4578-899X)
- Shrey Ramnath
- Alyssa L. Walker
- Leah A. Everitt (ORCID: https://orcid.org/0000-0003-0198-2512)
- Venetia A. Whiteside
- Piper A. Wilburn
- Divya Pillutla
- Gavin P. Kinsella
Institutions
- Indiana University Health (US)
- Purdue University West Lafayette (US)
- University Hospitals of Cleveland (US)
- Summa Akron City Hospital (US)
- Agri Processing Services (United States) (US)
- Hospital Metropolitano (EC)
- University School (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Case Western Reserve University (US)
- Indiana University (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0121
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Orthopaedic Research and Education Foundation
- Rally Foundation
- International Max Planck Research School for Advanced Methods in Process and Systems Engineering
- Scheme for Promotion of Academic and Research Collaboration
- National Institutes of Health
- Centers for Disease Control and Prevention
- University of Texas MD Anderson Cancer Center
- School of Medicine, Indiana University
- National Cancer Institute