Association Between Liver Fibrosis and Cause‐Specific Mortality in Japanese Patients With Biopsy‐Confirmed Metabolic Dysfunction–Associated Steatotic Liver Disease: A Prospective Cohort Study / Liver Fibrosis and Mortality in Japanese MASLD
HCC and extrahepatic malignancies were the leading causes of death in Japanese patients with MASLD. Liver fibrosis was a significant predictor of both all-cause and liver-related mortalities, but not nonliver-related mortality, highlighting its importance in follow-up strategies for MASLD. MASH may contribute to increased nonliver-related deaths. Further long-term studies are warranted.
Authors
- Yasuhide Mitsumoto (ORCID: https://orcid.org/0000-0002-1471-9062)
- Takeshi Okanoue (ORCID: https://orcid.org/0000-0002-2390-3400)
- Toshihide Shima (ORCID: https://orcid.org/0000-0002-4120-9121)
- Shinsaku Fujiishi
- Masayuki Mizuno (ORCID: https://orcid.org/0000-0002-1924-9856)
- Takahiro Nonaka (ORCID: https://orcid.org/0000-0002-3606-7165)
- Hirohisa Oya
- Kei Terasaki (ORCID: https://orcid.org/0000-0001-8964-8396)
- Takahiro Miura (ORCID: https://orcid.org/0000-0003-4180-6556)
- Shohei Amioka
- Kyoko Sakai
- Kohei Fukumoto
- Keiichiro Okuda
Institutions
- Suita Municipal Hospital (JP)
- Saiseikai Suita Hospital (JP)
- Nara Medical University (JP)
Publication Details
- Journal
- Hepatology Research
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1111/hepr.70034
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71