Single-cell transcriptomic analysis reveals the association of Ccl6+Ccr2+Arg1+ macrophages with renal interstitial fibrosis in AKI
Targeting the Ccl6/Ccr2 axis may attenuate fibrotic progression and offers potential therapeutic insights for preventing the transition from AKI to CKD, a possibility that warrants further validation through future functional experiments.
Authors
- Tao Xu (ORCID: https://orcid.org/0000-0002-8260-9754)
- Xin Xiao Zheng (ORCID: https://orcid.org/0000-0003-3027-9551)
- Jiayu Wang (ORCID: https://orcid.org/0000-0001-5957-4840)
- Qingquan Xu
- Weinan Chen (ORCID: https://orcid.org/0009-0009-5233-6247)
- Liang Chen
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Peking University People's Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1371/journal.pone.0332026
- Citations
- 2
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 2.86