Cut-Off Values And Pepsin Levels As Risk Factors For Laryngeal Carcinoma

Background: Laryngeal carcinoma is the most prevalent malignancy of the larynx, with smoking and alcohol being the primary risk factors. HPV and Helicobacter pylori infections, LPR, genetic factors, and betel nut consumption are the most common risk factors. The purpose of this study is to describe the correlation between pepsin levels and laryngeal carcinoma. Methods: This study investigated the correlation between pepsin levels and laryngeal carcinoma. ELISA is utilized to quantify pepsin values in patients' saliva. Data analysis included logistic regression, and the ROC curve was used to determine the pepsin cut-off value. Results: This study analyzed 36 laryngeal carcinoma with a majority of male patients (100%) and 36 patients as a control group. The most prevalent age distribution for laryngeal cancer patients is 60 to 70 years, with an age range of 36 to 82 years and an average age of 59.69 years. A history of smoking was present in 88.89% of carcinoma cases compared to 52.8% in the control group, showing a strong association between smoking and laryngeal carcinoma (p=0.002, OR=9.718). Logistic regression analysis confirmed a strong correlation between elevated pepsin levels and laryngeal carcinoma (p = 0.018, OR = 1.072). Pepsin levels in patients with laryngeal carcinoma had a cut-off value of 27.4 ng/ml. Conclusions: Elevated pepsin levels are significantly correlated with the occurrence of laryngeal carcinoma.