Study on the effect of modified Liu-an decoction on Th1/Th2 function in Guinea pigs with cough variant asthma through the Notch signal pathway
The addition of Liuan Decoction to the lungs can clear lungs and remove heat and strengthen the spleen to resolve phlegm, congestion, edema degree, reduce airway inflammation, and at the same time can reduce peri-tracheal collagen deposition, effectively improve airway remodeling, by regulating the dynamic balance of Th1/Th2. The specific downstream regulatory mechanisms of Notch signaling pathway need to be explored in further studies.
Authors
- Fangwei Xu (ORCID: https://orcid.org/0009-0005-8339-2824)
- Yuhang Chen (ORCID: https://orcid.org/0009-0009-1579-5479)
- K. Leow
- Liqun Wu (ORCID: https://orcid.org/0009-0001-6395-6822)
- Lu Chen (ORCID: https://orcid.org/0000-0002-5491-1841)
- Ningning Zhang (ORCID: https://orcid.org/0000-0002-5507-7713)
- Panpan Li (ORCID: https://orcid.org/0000-0003-3861-0587)
- Ye Zhang (ORCID: https://orcid.org/0000-0002-0627-7057)
- Jian Deng (ORCID: https://orcid.org/0000-0001-9442-0820)
Institutions
- Beijing University of Chinese Medicine (CN)
- Minhang District Central Hospital (CN)
- Guangzhou Women and Children Medical Center (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Institute of Medical Biology (SG)
- Beijing Fengtai Hospital (CN)
- Beijing Chaoyang Emergency Medical Center (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1371/journal.pone.0327356
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00