Re-evaluating malarial retinopathy to improve its diagnostic accuracy in paediatric cerebral malaria: A retrospective study
Malarial retinopathy remains the most specific point-of-care test for CM in endemic areas. Its specificity may be improved, without sacrificing sensitivity, by reclassifying patients in whom the only retinal sign is fewer than 5 haemorrhages in a single eye as malarial retinopathy negative. A management algorithm is proposed for integration of malarial retinopathy into clinical care in both well-resourced and resource-limited environments.
Authors
- Christopher A. Moxon (ORCID: https://orcid.org/0000-0001-6087-9393)
- Nicholas A. V. Beare (ORCID: https://orcid.org/0000-0001-8086-990X)
- Ian J. C. MacCormick (ORCID: https://orcid.org/0000-0002-8171-0332)
- Terrie E. Taylor (ORCID: https://orcid.org/0000-0001-7416-3986)
- Owen Banda (ORCID: https://orcid.org/0009-0001-1159-6634)
- Alice M. Liomba
- Karl B. Seydel (ORCID: https://orcid.org/0000-0001-9859-9549)
- Kyle J. Wilson (ORCID: https://orcid.org/0000-0003-0151-7530)
- Simon Harding (ORCID: https://orcid.org/0000-0003-4676-1158)
Institutions
- University of Liverpool (GB)
- Aintree University Hospitals NHS Foundation Trust (GB)
- Malawi-Liverpool-Wellcome Trust Clinical Research Programme (MW)
- Michigan United (US)
- Kamuzu University of Health Sciences (MW)
- University of Glasgow (GB)
- Michigan State University (US)
- University of Edinburgh (GB)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1371/journal.pmed.1004727
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00