Pseudo‐Hypoaldosteronism Type 2 due to New Variants of <scp>KLHL3</scp> Gene Diagnosed in an Adult Woman With Very High Sensitivity to Hydrochlorothiazide
We report a case of pseudo-hypoaldosteronism type 2 (PHA II) in a hypertensive 55-year-old woman who carried new variants of the KLHL3 gene. Hypersensitivity to hydrochlorothiazide was noted. Low dosages of hydrochlorothiazide were needed to restore potassium levels. PHA II must be excluded in adult hypertensive subjects with unexplained hyperkalemia.
Authors
- Carmela Caputo (ORCID: https://orcid.org/0000-0003-0864-0224)
- Monica Repetto
- Massimo Giusti (ORCID: https://orcid.org/0000-0002-1269-8376)
Institutions
- Ospedale San Paolo (IT)
- Ospedale San Paolo (IT)
- Santobono Children's Hospital (IT)
- Centro Diagnostico Italiano (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Clinical Case Reports
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/ccr3.70897
- Primary Topic
- Ion Transport and Channel Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Padova