<scp> H <sub>2</sub> O <sub>2</sub> </scp> ‐Producing Electrochemical Bandages Are Active Using Off‐the‐Shelf Hydrogels
An electrochemical bandage (e-bandage) that generates hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) through a combination of working, counter and reference electrodes used with an electrolyte-providing hydrogel is being developed for wound infection management. e-Bandage biocidal activity was previously demonstrated using Xanthan gum hydrogel. For clinical use, clinically used hydrogels would be ideal, but their use with the described e-bandage has not been shown. The goal of this work was to evaluate the biocidal activity of off-the-shelf, clinically used hydrogels when used with a 1.77 cm<sup>2</sup> H<sub>2</sub>O<sub>2</sub>-producing e-bandage. e-Bandage electrochemical parameters and activity against methicillin-resistant Staphylococcus aureus IDRL-6169 and Acinetobacter baumannii ATCC-17978 biofilms were assessed with six off-the-shelf hydrogels. Variations in hydrogel composition affected electrochemical parameters, which was associated with differences in biocidal activity. Results of this study inform the selection of off-the-shelf hydrogels for use with H<sub>2</sub>O<sub>2</sub>-producing e-bandages.
Authors
- Eda Dağsuyu (ORCID: https://orcid.org/0000-0003-0395-1058)
- Haluk Beyenal (ORCID: https://orcid.org/0000-0003-3931-0244)
- Robin Patel (ORCID: https://orcid.org/0000-0001-6344-4141)
- Paige J. Kies (ORCID: https://orcid.org/0000-0002-1665-8902)
Institutions
- Mayo Clinic (US)
- Istanbul University-Cerrahpaşa (TR)
- Mayo Clinic in Florida (US)
- Washington State University (US)
Publication Details
- Journal
- Wound Repair and Regeneration
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1111/wrr.70092
- Primary Topic
- Electrospun Nanofibers in Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases