Disability and quality of life assessment using WHODAS-12 items 2.0 and EQ-5D-5L in a rural area endemic for loiasis in the Republic of Congo: A population-based cross-sectional study (the MorLo project)
The impact of loiasis on daily QoL appears to be primarily due to adult worms rather than microfilarial density. Indeed, our findings strongly suggest that the number of Ew episodes, likely reflecting the cumulative burden of adult worms, is the main correlate of worse QoL scores. These episodes seem to affect multiple dimensions of functioning, with notable impact on mobility, pain, anxiety, and daily activities. In contrast, microfilariae would primarily induce organ dysfunction. Further studies are needed to better understand the respective clinical impacts of adult worms and L. loa microfilariae.
Authors
- Jérémy T. Campillo (ORCID: https://orcid.org/0000-0002-4400-5204)
- François Missamou (ORCID: https://orcid.org/0000-0002-6388-0266)
- Ludovic G. Rancé
- Marlhand C. Hemilembolo
- Samuel Bénéteau (ORCID: https://orcid.org/0000-0002-5922-3503)
- Cédric B. Chesnais (ORCID: https://orcid.org/0000-0002-8779-977X)
- Valentin Dupasquier (ORCID: https://orcid.org/0009-0009-1926-2231)
- Ange Clauvel Niama
- Michel Boussinesq (ORCID: https://orcid.org/0000-0001-6312-0681)
- Elodie Lebredonchel (ORCID: https://orcid.org/0000-0001-5119-6005)
- Sébastien D. S. Pion (ORCID: https://orcid.org/0000-0002-9468-7020)
- R Bileckot
- Glorifié Madoulou Moulabou
Institutions
- Inserm (FR)
- Université de Montpellier (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpitaux Universitaires Paris-Ouest (FR)
- Ministère De La Santé (BF)
- Institut de Recherche pour le Développement (FR)
- Marien Ngouabi University (CG)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1371/journal.pntd.0013491
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00