Microwave Irradiation Mediated Synthesis of Quinazolinones Over Amberlyst‐15 Ion‐Exchange Resins

Abstract Microwave chemistry has become a well‐established technique with several benefits interms of reaction rate and manufacturing yield, leading to energy savings assupported by numerous commercial applications. Fe@AR catalyst offers several advantages asa solid acid catalyst, including enhanced acidity from stronger Lewis acidsites, improved thermal, and higher selectivity in organic reactions. The quinazolinone skeleton possesses significantpharmacological and therapeutic properties, including antibacterial, analgesic, anti‐inflammatory, antifungal, antimalarial, central nervous system depressant, anticonvulsant, anti‐parkinsonian, anticancer, etc. In the present study, quinazolinones and their derivatives have been synthesized using Amberlystresin (A‐15) and Fe³⁺‐modified Amberlyst (Fe@AR) as solid acid catalysts undermicrowave irradiation. Fe@AR catalyst has been characterized using various analytical techniques, including XRD, FT‐IR, SEM‐EDX, and TGA. The studied catalysed cyclocondensation reaction for the 2,3‐dihydroquinazolines(2,3‐DHQZs) synthesis, is monitored by TLC. One novel derivative has been synthesized and was confirmed by 1H NMR, 13C NMR andFT‐IR spectroscopy. The key benefits of the present protocol are their quick reaction times, simple workup, and, their environmental friendliness.