Single-cell multiomic modelling of early metastatic events promoted by the extracellular matrix
This study presents an advanced in vitro model that closely recapitulates in situ tumorigenesis and provides novel insights into the metastatic cascade. The pdECM system enables the reconstruction of EMT dynamics, highlighting the critical role of ECM composition in metastasis and offering a physiologically relevant platform for the development of targeted therapies.
Authors
- Jung Kyoon Choi (ORCID: https://orcid.org/0000-0003-2077-8947)
- Woong‐Yang Park (ORCID: https://orcid.org/0000-0003-4234-0380)
- Youngwon Cho
- Pilnam Kim (ORCID: https://orcid.org/0000-0002-5592-4599)
- Junho Kang (ORCID: https://orcid.org/0000-0003-3430-0960)
- Hyun Jin Lee (ORCID: https://orcid.org/0000-0001-9259-0332)
- Joonha Kwon (ORCID: https://orcid.org/0000-0002-6607-0277)
- Kyeonghui Kim
- Tae‐You Kim (ORCID: https://orcid.org/0000-0001-5500-0794)
- Jun Hyeong Lee
- Sang‐Hyun Song (ORCID: https://orcid.org/0000-0002-9208-9537)
- Jihyun Park (ORCID: https://orcid.org/0000-0002-1926-3607)
- Young‐Joon Kim (ORCID: https://orcid.org/0000-0003-1397-8166)
- Jong-Eun Park (ORCID: https://orcid.org/0000-0002-1687-2423)
Institutions
- Seoul National University (KR)
- Korea Advanced Institute of Science and Technology (KR)
- Yonsei University (KR)
- Nexen (Canada) (CA)
- Samsung Medical Center (KR)
- Seoul National University Hospital (KR)
- National Cancer Center (US)
- National Cancer Center (KR)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1038/s41416-025-03181-4
- Citations
- 1
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Research Foundation
- Ministry of Science, ICT and Future Planning
- Korea Advanced Institute of Science and Technology
- Ministry of Science and ICT, South Korea