Perioperative Radiotherapy and Survival After Surgical Treatment of Nonmetastatic Retroperitoneal Sarcoma
The rate of perioperative RT use was lowest in well-differentiated retroperitoneal liposarcoma. Conversely, perioperative RT was used at approximately twice that rate in dedifferentiated liposarcoma and leiomyosarcoma. These findings are discordant with the most recent guideline recommendations but should be interpreted in the context of the historical nature of the investigated cohort, which predates the publication of those guidelines. Perioperative RT was not associated with differences in cancer-specific mortality across any of the 3 examined retroperitoneal sarcoma histologic subtypes. Unfortunately, local recurrence, surgical margin status, and metastatic progression rates could not be addressed.
Authors
- Zhe Tian (ORCID: https://orcid.org/0000-0002-9482-6473)
- Gianluigi Califano
- Francesco Di Bello (ORCID: https://orcid.org/0000-0002-8585-3701)
- Felix K.‐H. Chun (ORCID: https://orcid.org/0000-0001-8486-9536)
- Carolin Siech (ORCID: https://orcid.org/0000-0002-5460-4171)
- Jordan A. Goyal (ORCID: https://orcid.org/0009-0006-4609-8981)
- Damiano Vizziello
- Ottavio De Cobelli (ORCID: https://orcid.org/0000-0002-0699-8620)
- Letizia Maria Ippolita Jannello (ORCID: https://orcid.org/0000-0002-0612-0519)
- Fred Saad (ORCID: https://orcid.org/0000-0003-2986-5617)
- Mario de Angelis (ORCID: https://orcid.org/0009-0008-0494-7839)
- Andrea Baudo (ORCID: https://orcid.org/0000-0003-0746-2876)
- Luca Carmignani (ORCID: https://orcid.org/0000-0002-3152-1744)
- Nicola Longo (ORCID: https://orcid.org/0000-0002-3677-1216)
- Andrea Conti
- Pietro Acquati
- Pierre I. Karakiewicz
- Alberto Briganti
- Shahrokh F. Shariat
Institutions
- Al-Ahliyya Amman University (JO)
- Goethe University Frankfurt (DE)
- Vita-Salute San Raffaele University (IT)
- Cornell University (US)
- Comprehensive Cancer Center Vienna (AT)
- IRCCS Policlinico San Donato (IT)
- University Hospital Frankfurt (DE)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- European Institute of Oncology (IT)
- Université de Montréal (CA)
- University of Naples Federico II (IT)
- Medical University of Vienna (AT)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal of the National Comprehensive Cancer Network
- Published
- 2025-09-15
- DOI
- https://doi.org/10.6004/jnccn.2025.7056
- Citations
- 1
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52