Association of HOXB13 G84E With Prostate Cancer Among 592,158 Men
In the largest cohort of men with the HOXB13 p.G84E variant studied to date, we demonstrate a moderately increased lifetime risk of PrCa. However, the PrCa that develops is not more aggressive, although it may occur at younger ages. Further research is warranted to determine whether early PrCa screening in HOXB13 p.G84E heterozygotes improves outcomes.
Authors
- Morgan E. Danowski
- Kathleen A. Cooney (ORCID: https://orcid.org/0000-0003-3831-6943)
- Jason L. Vassy (ORCID: https://orcid.org/0000-0001-6113-5564)
- Meghana S. Pagadala (ORCID: https://orcid.org/0000-0002-7591-6035)
- Jeffrey R. Smith
- Scott L. DuVall (ORCID: https://orcid.org/0000-0002-4898-3865)
- Brent Shane Rose (ORCID: https://orcid.org/0000-0002-3197-9552)
- Julie Ann Lynch (ORCID: https://orcid.org/0000-0003-0108-2127)
- Richard L. Hauger (ORCID: https://orcid.org/0000-0003-1509-1868)
- Taylor Crawford
- Kara N. Maxwell (ORCID: https://orcid.org/0000-0001-8192-4202)
- Tyler M. Seibert (ORCID: https://orcid.org/0000-0002-4089-7399)
- Désirée Ratner (ORCID: https://orcid.org/0000-0002-1217-1929)
- Ryan Hausler
- Charles A. Brunette (ORCID: https://orcid.org/0000-0003-1620-3526)
- Craig C. Teerlink (ORCID: https://orcid.org/0000-0002-1992-2326)
- Patrick R. Alba (ORCID: https://orcid.org/0000-0002-5176-5447)
- Isla P. Garraway (ORCID: https://orcid.org/0000-0002-1129-4636)
- Tyler J. Nelson (ORCID: https://orcid.org/0000-0001-5216-7337)
- Hannah Carter (ORCID: https://orcid.org/0000-0002-1729-2463)
- Heena Desai (ORCID: https://orcid.org/0000-0002-9710-4468)
- Roshan Karunamuni (ORCID: https://orcid.org/0000-0001-8723-8123)
Institutions
- Canadian Institute for Advanced Research (CA)
- Brigham and Women's Hospital (US)
- Memorial Sloan Kettering Cancer Center (US)
- Harvard University (US)
- University of California, Los Angeles (US)
- Duke University (US)
- University of Utah (US)
- VA Boston Healthcare System (US)
- University of California San Diego (US)
- VA Salt Lake City Healthcare System (US)
- VA San Diego Healthcare System (US)
- Precision for Medicine (United States) (US)
- Duke Medical Center (US)
- University of California San Diego Medical Center (US)
- Philadelphia VA Medical Center (US)
- La Jolla Bioengineering Institute (US)
- VA Greater Los Angeles Healthcare System (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Journal of the National Comprehensive Cancer Network
- Published
- 2025-09-15
- DOI
- https://doi.org/10.6004/jnccn.2025.7055
- Primary Topic
- Connective Tissue Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00