Chemical constituents of the stem bark of <i>Grewia schweinfurthii</i> with antioxidant and antibacterial activities

<i>Grewia schweinfurthii</i>, a deciduous shrub from the Malvaceae family, has been traditionally used in for treating wound infection, stomach disorder, snake bite, chest pain, and cough and skin diseases. The research aimed to analyse the plant's chemical composition and its effectiveness against antibacterial and antioxidant activity. Different standard methods were employed to screen the phytochemical classes of compounds. Three compounds were isolated from the plant's stem barks and identified as betulin dibenzoate, lauric acid, and 5β-pregnane. The isolated compounds and the plant's crude extracts were tested against bacteria, and crude extracts were tested against oxidative stress. Both the crude extract and isolated compounds demonstrated promising activity against antibacterial activities. The crude extract showed significant antioxidant activity. In general, the results suggest potential for further exploration of <i>G. schweinfurthii</i> chemical constituents and their use in treating bacterial and oxidative stress-related diseases.

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Publication Details

Journal
Natural Product Research
Published
2025-09-15
DOI
https://doi.org/10.1080/14786419.2025.2559756
Primary Topic
African Botany and Ecology Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Chemical constituents of the stem bark of Grewia schweinfurthii with antioxidant and antibacterial activities

Bekalu Getachew, Bekele Lemma, Shahzad Hamza, Elsabet Defaru et al.
Natural Product Research
African Botany and Ecology Studies
article

Chemical constituents of the stem bark of Grewia schweinfurthii with antioxidant and antibacterial activities

Bekalu Getachew, Bekele Lemma, Shahzad Hamza, Elsabet Defaru, Dagne Adisu, Abdulkerim Abdela
article en

Abstract

<i>Grewia schweinfurthii</i>, a deciduous shrub from the Malvaceae family, has been traditionally used in for treating wound infection, stomach disorder, snake bite, chest pain, and cough and skin diseases. The research aimed to analyse the plant's chemical composition and its effectiveness against antibacterial and antioxidant activity. Different standard methods were employed to screen the phytochemical classes of compounds. Three compounds were isolated from the plant's stem barks and identified as betulin dibenzoate, lauric acid, and 5β-pregnane. The isolated compounds and the plant's crude extracts were tested against bacteria, and crude extracts were tested against oxidative stress. Both the crude extract and isolated compounds demonstrated promising activity against antibacterial activities. The crude extract showed significant antioxidant activity. In general, the results suggest potential for further exploration of <i>G. schweinfurthii</i> chemical constituents and their use in treating bacterial and oxidative stress-related diseases.

Natural Product Research
Hawassa University (ET), Jining University (CN), Arba Minch University (ET), Jinka University
Openalex Percentile: Top 70%
African Botany and Ecology Studies
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