Twenty-year pancreatic metastasis from renal cell carcinoma

Renal cell carcinoma accounts for approximately 90% of all primary renal cancers. Generally associated with a favorable prognosis, its natural history may show a low propensity for metastatic spread. Although distant seeding can involve various organs, secondary pancreatic malignancies are rare and challenging to diagnose, particularly when presenting as solitary lesions that may be mistaken for primary pancreatic carcinoma. We present the medical record of a patient diagnosed with renal cell carcinoma who underwent nephrectomy and developed pancreatic metastasis 20 years later. The significance of this case lies in raising awareness of this possibility and considering such a diagnosis when a pancreatic mass is discovered in patients with a history of renal cell carcinoma surgery.