Multimarker Cerebral Small Vessel Disease Score and Risk of Incident Dementia in the Framingham Heart Study
We found a significant association between all-cause dementia and multimarker CSVD scores, which was independent of the FSRP as well as its individual components. Our results support the use of a multimarker CSVD score as an indicator for incident all-cause dementia risk and suggest that it may be as robust as the FSRP. Further studies are necessary to validate the use of a multimarker CSVD score in dementia risk prediction.
Authors
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Jose Rafael Romero (ORCID: https://orcid.org/0000-0002-1101-2950)
- Adlin Pinheiro (ORCID: https://orcid.org/0000-0002-4241-9198)
- Hugo J. Aparicio (ORCID: https://orcid.org/0000-0001-8584-1455)
- Oluchi Ekenze (ORCID: https://orcid.org/0000-0002-2510-8427)
- Alexa S. Beiser (ORCID: https://orcid.org/0000-0001-8551-7778)
- Serkalem Demissie (ORCID: https://orcid.org/0000-0002-8009-0987)
- Charles S DeCarli (ORCID: https://orcid.org/0000-0003-1914-2693)
Institutions
- Boston University (US)
- The University of Texas at San Antonio Health Science Center (US)
- Institute for Neurodegenerative Disorders (US)
- Framingham Heart Study (US)
- University of California, Davis (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1212/wnl.0000000000214113
- Citations
- 4
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.56
Funders
- National Institutes of Health