Risk of Epilepsy and Factors Associated With Time to Seizure Remission in Anti-LGI1 Encephalitis
In conclusion, our results demonstrate that AEAE in anti-LGI1 encephalitis is rare and suggest that the diagnosis of epilepsy is inappropriate in patients reaching seizure remission because of a relatively low ROSR. Accordingly, on seizure remission, the diagnosis of acute symptomatic seizures would be appropriate. Moreover, we validate and quantify the importance of IT for seizure remission and identify biomarkers associated with lower rates of seizure remission. Late remission of seizures and AEAE were associated with persistent cognitive impairment.
Authors
- Hauke Schneider (ORCID: https://orcid.org/0000-0002-9641-0922)
- Walid Fazeli (ORCID: https://orcid.org/0000-0002-9425-5535)
- Henrik Rohner
- Jan Lewerenz (ORCID: https://orcid.org/0000-0002-9272-529X)
- Simon Schuster (ORCID: https://orcid.org/0000-0001-6038-0138)
- Albert J. Becker (ORCID: https://orcid.org/0000-0003-2661-3705)
- Olga Simova
- Christian Hofmann (ORCID: https://orcid.org/0000-0002-1703-4800)
- Marina Flotats‐Bastardas (ORCID: https://orcid.org/0000-0001-7696-4808)
- Sonka Benesch
- Rolf Kern
- Philip Hillebrand
- Sebastian Baatz
- Felix Fischbach
- Marie Madlener (ORCID: https://orcid.org/0000-0002-6299-8238)
- Claudia Sommer (ORCID: https://orcid.org/0000-0002-7064-5002)
- Brigitte Wildemann (ORCID: https://orcid.org/0000-0002-5389-3338)
- Hiltrud Muhle
- Martin Lesser (ORCID: https://orcid.org/0000-0002-0318-5739)
- Makbule Şenel (ORCID: https://orcid.org/0000-0002-2737-7495)
- Felix von Podewils (ORCID: https://orcid.org/0000-0002-3134-8697)
- Franziska S. Thaler (ORCID: https://orcid.org/0000-0001-6548-0410)
- Max Kaufmann (ORCID: https://orcid.org/0000-0002-1954-4425)
- Hagen B. Huttner (ORCID: https://orcid.org/0000-0002-0992-8871)
- Constanze Kerin
- Jost Obrocki
- Manuel Alexander Friese (ORCID: https://orcid.org/0000-0001-6380-2420)
- Jan D. Lünemann (ORCID: https://orcid.org/0000-0002-3007-708X)
- Luise Appeltshauser (ORCID: https://orcid.org/0000-0001-5248-4009)
- Susanne Knake (ORCID: https://orcid.org/0000-0002-6298-0513)
- Iason Bartzokis
- Sigrid Reuter
- Johannes Piepgras
- Sarah Bernsen (ORCID: https://orcid.org/0000-0001-7485-2626)
- Achim Berthele (ORCID: https://orcid.org/0000-0001-9650-6222)
- Yavor Yalachkov (ORCID: https://orcid.org/0000-0002-0805-771X)
- Birgit Berger
- Sandra Stanković (ORCID: https://orcid.org/0000-0003-3114-0869)
- Jens Schmidt
- Katharina Eisenhut (ORCID: https://orcid.org/0000-0001-6448-3126)
- Simone C. Tauber (ORCID: https://orcid.org/0000-0001-9149-3071)
- Frank Leypoldt (ORCID: https://orcid.org/0000-0002-8972-515X)
- Timo Deba
- Fabian Möller (ORCID: https://orcid.org/0000-0001-6877-8327)
- Annette Baumgärtner
- Annika Kather
- Christian Urbanek
- Mathias Fousse (ORCID: https://orcid.org/0000-0001-5489-1492)
- Carlos Martínez Quesada (ORCID: https://orcid.org/0000-0002-2213-7767)
- Martin Häusler (ORCID: https://orcid.org/0000-0002-8433-8919)
- Regina Trollmann (ORCID: https://orcid.org/0000-0001-6031-8537)
- Gernot Reimann (ORCID: https://orcid.org/0000-0001-7019-6975)
- Peter Huppke (ORCID: https://orcid.org/0009-0004-1183-4905)
- Markus Rauchenzauner
- Tobias Freilinger
- Inga Koneczny (ORCID: https://orcid.org/0000-0002-0567-021X)
- Felix Rosenow (ORCID: https://orcid.org/0000-0002-3989-7471)
- Aiden Haghikia (ORCID: https://orcid.org/0000-0001-9629-3298)
- Klaus‐Peter Wandinger (ORCID: https://orcid.org/0000-0002-5483-4276)
- Johanna Maria Helena Rau (ORCID: https://orcid.org/0000-0002-5186-3338)
- Michael Karenfort (ORCID: https://orcid.org/0000-0002-8925-3543)
- Harald Prüß (ORCID: https://orcid.org/0000-0002-8283-7976)
- Ulrich Hofstadt‐van Oy (ORCID: https://orcid.org/0000-0003-4956-597X)
- Yvette S. Crijnen (ORCID: https://orcid.org/0000-0003-0279-7140)
- Dietrich Sturm
- Anna Rada (ORCID: https://orcid.org/0000-0003-2538-0786)
- Sven Guenther Meuth (ORCID: https://orcid.org/0000-0003-2571-3501)
- Judith Wagner (ORCID: https://orcid.org/0000-0002-0776-6821)
- Anja Tietz
- Marius Ringelstein (ORCID: https://orcid.org/0000-0003-3618-8407)
- Verena Kraus
- Christos Krogias (ORCID: https://orcid.org/0000-0003-2965-4051)
- Saskia Räuber (ORCID: https://orcid.org/0000-0001-8901-5572)
- Sergio Castro‐Gomez (ORCID: https://orcid.org/0000-0002-1581-474X)
- Mona Dreesmann
- Christoph Kellinghaus (ORCID: https://orcid.org/0000-0001-5491-2302)
- Yannic Saathoff
- Stefan Bittner (ORCID: https://orcid.org/0000-0003-2179-3655)
- Oliver Bähr (ORCID: https://orcid.org/0000-0003-2073-037X)
- Marina Entscheva
- Lara Zieger
- Niklas Vogel (ORCID: https://orcid.org/0009-0004-1461-2419)
- Lucia Campetella (ORCID: https://orcid.org/0000-0003-3415-6428)
- Mareike Jansen
- Oliver Stammel
- Julika Pitsch (ORCID: https://orcid.org/0000-0002-6688-4916)
- Britta Greshake
- Sigrid Mues
- Daniela Esser
- Kerstin Hellwig (ORCID: https://orcid.org/0000-0003-4467-9011)
- Robert Weissert (ORCID: https://orcid.org/0000-0002-1295-1271)
- Ruth Schilling
- Thomas Grüter (ORCID: https://orcid.org/0000-0001-8927-9818)
- Jens Kühle (ORCID: https://orcid.org/0000-0002-6963-8892)
- Anna Gorsler (ORCID: https://orcid.org/0000-0001-5980-0983)
- Rosa Rößling (ORCID: https://orcid.org/0000-0003-2253-1454)
- Péter Körtvelyessy (ORCID: https://orcid.org/0000-0003-1262-6169)
- Kurt‐Wolfram Sühs (ORCID: https://orcid.org/0000-0002-8077-481X)
- Kim Kristin Falk (ORCID: https://orcid.org/0000-0002-3573-9257)
- Astrid Blaschek (ORCID: https://orcid.org/0000-0003-2918-0159)
- Steffen Pfeuffer (ORCID: https://orcid.org/0000-0001-5171-4845)
- Jan Wagner (ORCID: https://orcid.org/0000-0002-0459-8885)
- Karsten Witt (ORCID: https://orcid.org/0000-0002-9384-3474)
- Dirk Fitzner (ORCID: https://orcid.org/0000-0002-2511-6216)
- Joachim Havla (ORCID: https://orcid.org/0000-0002-4386-1340)
- Raphael Reinecke (ORCID: https://orcid.org/0000-0001-8852-7234)
- Kevin M. Rostasy (ORCID: https://orcid.org/0000-0002-2180-5321)
- Karl‐Christian Thies (ORCID: https://orcid.org/0000-0001-9939-4166)
- Josef Priller (ORCID: https://orcid.org/0000-0001-7596-0979)
- Maarten J. Titulaer (ORCID: https://orcid.org/0000-0002-1033-3840)
- Tobias Bauer (ORCID: https://orcid.org/0000-0002-0555-6214)
- Friedemann Paul (ORCID: https://orcid.org/0000-0002-6378-0070)
- Michael P. Malter (ORCID: https://orcid.org/0000-0003-2535-4553)
- Andre Dik (ORCID: https://orcid.org/0000-0003-4695-4136)
- Charlotte Behning (ORCID: https://orcid.org/0000-0002-9310-3804)
- Hayrettin Tumani (ORCID: https://orcid.org/0000-0002-7921-9966)
- Alexander Emmer (ORCID: https://orcid.org/0000-0003-4272-8887)
- Michelle Braun
- Henning Stolze
- Jérôme Honnorat (ORCID: https://orcid.org/0000-0002-4721-5952)
- Corinna Trebst
- Catharina C. Groß (ORCID: https://orcid.org/0000-0002-4872-9189)
- Kathrin Doppler (ORCID: https://orcid.org/0000-0003-2883-0009)
- Aleksandra Juranek
- Robert L. Berger
- Kai Siebenbrodt (ORCID: https://orcid.org/0000-0003-3827-4245)
- Laura Ehrhardt
- Carolin Baade‐Büttner (ORCID: https://orcid.org/0009-0000-3098-5961)
- Alexandra Philipsen (ORCID: https://orcid.org/0000-0001-6876-518X)
- Stjepana Kovac (ORCID: https://orcid.org/0000-0002-2500-6893)
- Martin Berghoff (ORCID: https://orcid.org/0000-0001-7954-3646)
- Klaus Berger (ORCID: https://orcid.org/0000-0001-8966-3684)
- Thomas Pfefferkorn (ORCID: https://orcid.org/0000-0002-7072-0295)
- Nico Melzer (ORCID: https://orcid.org/0000-0002-2420-701X)
- Thorleif Etgen (ORCID: https://orcid.org/0000-0002-7857-6435)
- Christine Strippel (ORCID: https://orcid.org/0000-0002-7080-6769)
- Robert Rehmann (ORCID: https://orcid.org/0000-0003-1429-4399)
- Valentin Held
- Sergio Muñiz‐Castrillo (ORCID: https://orcid.org/0000-0001-5958-3288)
- Justina Dargvainiene (ORCID: https://orcid.org/0009-0002-4114-3748)
- Robert Handreka
- Marie‐Luise Mono (ORCID: https://orcid.org/0000-0003-4886-0010)
- Loana Penner (ORCID: https://orcid.org/0009-0000-4250-0087)
- Jens Schaumberg
- Fatme Seval Ismail (ORCID: https://orcid.org/0000-0003-3930-8056)
- Christian G. Bien (ORCID: https://orcid.org/0000-0003-2225-8654)
- Thanos Tsaktanis
- Bettina Balint (ORCID: https://orcid.org/0000-0003-4127-8554)
- Gerd Meyer zu Hörste (ORCID: https://orcid.org/0000-0002-4341-4719)
- Florian Then Bergh (ORCID: https://orcid.org/0000-0001-8604-8408)
- Carsten Finke (ORCID: https://orcid.org/0000-0002-7665-1171)
- Lena Kristina Pfeffer (ORCID: https://orcid.org/0000-0003-3057-6492)
- Ina Reichen
- Christoph Lehrich
- Milene Schmitz
- Franz Blaes (ORCID: https://orcid.org/0000-0002-8628-095X)
- Patrick Schramm (ORCID: https://orcid.org/0000-0001-5158-6708)
- Daniel Rapp (ORCID: https://orcid.org/0000-0003-0453-7318)
- Armin Grau (ORCID: https://orcid.org/0000-0001-9339-6056)
- Ellen Knierim (ORCID: https://orcid.org/0000-0002-4769-7322)
- Sebastian Bauer (ORCID: https://orcid.org/0000-0001-7571-8496)
- Dominique Endres (ORCID: https://orcid.org/0000-0001-7322-1195)
- Til Menge (ORCID: https://orcid.org/0000-0003-3459-8867)
- Andreas van Baalen (ORCID: https://orcid.org/0000-0001-7988-5224)
- Anne‐Katrin Pröbstel (ORCID: https://orcid.org/0000-0002-7748-1872)
- Julian Dominik
- Alexander Finke
- Steffen Syrbe (ORCID: https://orcid.org/0000-0003-2543-4844)
- G Seidel (ORCID: https://orcid.org/0000-0003-2804-7735)
- Rainer Surges (ORCID: https://orcid.org/0000-0002-3177-8582)
- Mosche Pompsch (ORCID: https://orcid.org/0009-0005-0493-6409)
- Marc Nikolaus (ORCID: https://orcid.org/0000-0002-3678-5159)
- Tobias Baumgartner (ORCID: https://orcid.org/0000-0001-5935-9841)
- Jens Harmel (ORCID: https://orcid.org/0000-0002-0578-5973)
- Jonathan Wickel (ORCID: https://orcid.org/0000-0002-5854-3759)
- Antonios Bayas (ORCID: https://orcid.org/0000-0002-7418-9040)
- Antonia Harms (ORCID: https://orcid.org/0000-0001-9790-8127)
- Ilya Ayzenberg
- Christian Geis (ORCID: https://orcid.org/0000-0002-9859-581X)
- Muriel Stoppe
- Nele Retzlaff
- Klarissa Hanja Stürner (ORCID: https://orcid.org/0000-0003-2199-3315)
- Theodor Rüber (ORCID: https://orcid.org/0000-0002-6180-7671)
- Marco Gallus (ORCID: https://orcid.org/0009-0007-4954-8420)
- Ruth Kerkhoff
- Duygu Pul
- Jaqueline Klausewitz (ORCID: https://orcid.org/0009-0009-9880-1191)
- Chung Ha-Yeun
- Andeas Linsa
- Gesa Schreyer
- Methap Türedi
- Max Vogtmann
- Kartharina Wurdack
- Lena Edelhoff
- Yetzenia Dubraska Haro Alizo
- Áttila Rácz (ORCID: https://orcid.org/0000-0002-5952-8294)
- Niels Hansen (ORCID: https://orcid.org/0000-0002-1046-1113)
- Frank Seifert (ORCID: https://orcid.org/0000-0002-7065-2528)
- Stephan J. Rüegg (ORCID: https://orcid.org/0000-0002-5836-622X)
- George Trendelenburg (ORCID: https://orcid.org/0000-0001-9277-6241)
- Thomas Seifert‐Held (ORCID: https://orcid.org/0000-0001-8121-3662)
- Andreas Binder (ORCID: https://orcid.org/0000-0001-7795-1195)
- Stefanie Becker (ORCID: https://orcid.org/0000-0001-8503-6368)
- Stephan Schreiber (ORCID: https://orcid.org/0000-0003-4251-6067)
- Frank Hoffmann
- Corinna Bien
- Wolfgang Heide
- M. M. Gebhard
- Monika Meister
- Ina Schröder
- Felicitas Becker
- Jürgen Faiss
- Matthias von Mering
- Andrea Kraft (ORCID: https://orcid.org/0009-0001-3748-1798)
- Martina Jansen
- Sven Ehrlich
- Ina-Isabelle Schmütz
- Amelie Bohn
- Karin Storm van’s Gravesande
- Markus Krämer
- Romina-Anna-Maria Fernandez Ceballos
- Andeas Steinbrecher
- Julia Maren Decker
- Gregor Kuhlenbäumer
- Felix F. Konen
- Daniel Bittner (ORCID: https://orcid.org/0000-0001-9867-9274)
- Dominica Hudasch
- Frank Kohlert
- Anna-Katharina Mundorf
- Philip Schwenkenbecher
- Rem Vaizian
- Njiku Melchior Wellmer
- Julia Bierwith
- Johanna-Maria Dietmaier
- Jonas Marius
- Oliver Graue
- Juliane Spiegle
- Moritz Freyberg
- Nils Margra
- Yannik Hülsmann
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Goethe University Frankfurt (DE)
- Centre National de la Recherche Scientifique (FR)
- University of Bonn (DE)
- Inserm (FR)
- Zimmer Biomet (Netherlands) (NL)
- Bielefeld University (DE)
- University of Münster (DE)
- Universitätsmedizin Greifswald (DE)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- Erasmus MC (NL)
- University Hospital of Basel (CH)
- Medizinische Hochschule Hannover (DE)
- Humboldt-Universität zu Berlin (DE)
- Düsseldorf University Hospital (DE)
- University Hospital Münster (DE)
- Evangelisches Krankenhaus Bielefeld (DE)
- University Hospital Schleswig-Holstein (DE)
- Institut NeuroMyoGène (FR)
- Department of Biomedicine Basel (CH)
- University Hospital Frankfurt (DE)
- University Hospital Cologne (DE)
- University Hospital Ulm (DE)
- Heinrich Heine University Düsseldorf (DE)
- Medical University of Vienna (AT)
- Ludwig-Maximilians-Universität München (DE)
- RWTH Aachen University (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1212/nxi.0000000000200469
- Citations
- 1
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39