Effects of DOACs on Mouse Melanoma Metastasis and the Inhibitory Mechanism of Edoxaban, a Factor Xa-Specific DOAC
Among the tested DOACs, EDX showed the strongest inhibition of B16 cell metastasis in mice, likely via the suppression of inflammation, angiogenesis, and EMT mediated by the FXa-dependent PAR2 and TGFβ pathways in tumor and surrounding tissue cells.
Authors
- Shoji Imai (ORCID: https://orcid.org/0009-0001-0736-2237)
- T. Watanabe (ORCID: https://orcid.org/0000-0002-8567-1975)
- Koji Suzuki
- Keiichi Hiramoto (ORCID: https://orcid.org/0000-0001-5208-8719)
Institutions
- Suzuka University of Medical Science (JP)
Publication Details
- Journal
- TH Open
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1055/a-2701-4242
- Citations
- 1
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Japan Society for the Promotion of Science