Weekly Teriparatide Treatment Decreases Microdamage in Tibial Trabecular Bone of Ovariectomized Cynomolgus Monkeys
Weekly teriparatide administration attenuates tibial trabecular bone microdamage by restoring collagen cross-link balance, independent of bone mass gain. This suggests that teriparatide enhances bone quality and resistance to fracture via modulation of bone matrix integrity.
Authors
- Teppei Senda
- Masakazu Ishikawa (ORCID: https://orcid.org/0000-0002-8561-6028)
- Tasuku Mashiba (ORCID: https://orcid.org/0000-0001-6197-6283)
- Mitsuru Saito (ORCID: https://orcid.org/0000-0003-1653-4309)
- Ken Iwata
Institutions
- Jikei University School of Medicine (JP)
Publication Details
- Journal
- Cureus
- Published
- 2025-09-15
- DOI
- https://doi.org/10.7759/cureus.92396
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00