The <scp>PI3K</scp> Inhibitor <scp>HCD</scp> Promotes Caspase Activation in Head and Neck Squamous Cells by Upregulating the Extrinsic and Intrinsic Apoptosis Pathways
This investigation into HCD's molecular mechanisms in OSCC cells offers insight into developing effective anticancer therapies, highlighting its role in apoptosis induction through oxidative stress, mitochondrial pathways, and death receptor signaling.
Authors
- Ya‐Ping Tseng
- Pinqi Wang (ORCID: https://orcid.org/0009-0007-1160-1206)
- Chen‐Yu Chien (ORCID: https://orcid.org/0000-0002-2791-6874)
- Leong‐Perng Chan (ORCID: https://orcid.org/0000-0001-8192-2725)
- Che‐Wei Wu (ORCID: https://orcid.org/0000-0003-1052-5348)
- Chia‐Hua Liang (ORCID: https://orcid.org/0000-0001-8589-4805)
- Chih‐Chuang Liaw (ORCID: https://orcid.org/0000-0002-3552-3958)
- Ling‐Feng Wang (ORCID: https://orcid.org/0000-0001-8259-8699)
- Tung‐Wen Yen
- Hui‐Ching Wang (ORCID: https://orcid.org/0000-0002-8232-0387)
Institutions
- National Sun Yat-sen University (TW)
- Kaohsiung Medical University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Kaohsiung Municipal Hsiao-Kang Hospital (TW)
- Taipei Medical University (TW)
- Chia Nan University of Pharmacy and Science (TW)
- National Cheng Kung University (TW)
Publication Details
- Journal
- Journal of Oral Pathology and Medicine
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1111/jop.70060
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kaohsiung Medical University
- Kaohsiung Medical University Chung-Ho Memorial Hospital
- National Science and Technology Council