The eternal struggle between titans: Fecal microbiota transplant (FMT) versus metformin in type 2 diabetes (T2D) gut dysmotility
The physiological roles of the gut microbiota and their metabolites are explored, highlighting their contribution to the onset and progression of metabolic disorders, particularly T2D. We examined the mechanisms through which Metf and FMT influence gut microbiota, insulin sensitivity, and glucose tolerance. Novel therapeutic approaches, including the combined use of Metf and FMT, are discussed in terms of molecular mechanisms, clinical outcomes, and safety profiles. Finally, the potential integration of these strategies into T2D management and their impact on gastrointestinal dysfunction are considered as areas for further research.
Authors
- Jimmy Martín-Delgado (ORCID: https://orcid.org/0000-0003-4384-9197)
- Alessio Porta (ORCID: https://orcid.org/0000-0002-2564-9696)
- Massimiliano Corsi Romanelli
- Antonio Ettore Pontiroli (ORCID: https://orcid.org/0000-0002-8217-7672)
- Marco D’Anzeo
- Elena Dozio (ORCID: https://orcid.org/0000-0001-5833-0780)
- Lorenzo Drago (ORCID: https://orcid.org/0000-0002-5206-540X)
- Cesare Berra (ORCID: https://orcid.org/0000-0001-8431-8160)
- Valentina Carlini (ORCID: https://orcid.org/0000-0001-7592-1566)
- Elena Vianello (ORCID: https://orcid.org/0000-0001-6461-654X)
- Angelo Naselli (ORCID: https://orcid.org/0000-0003-3372-8068)
- Lucia La Sala (ORCID: https://orcid.org/0000-0002-7580-1377)
- Maria Belen Macas-Granizo
- Emilio Trabucchi
Institutions
- Marche Polytechnic University (IT)
- Universidad Católica de Santiago de Guayaquil (EC)
- MultiMedica (IT)
- Ospedale San Paolo (IT)
- Hospital Luis Vernaza (EC)
- IRCCS Istituto Auxologico Italiano (IT)
- Universidad Regional Amazónica IKIAM (EC)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.jare.2025.09.021
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42