Pancreatic cancer cells escape T/NK cell immune surveillance through the expressional separation of CD58
This study uncovers a novel vicious crosstalk among macrophages, T/NK cells, and PDAC cells within the tumor microenvironment. Macrophages drive the expressional separation of CD58 via the TGF-β/Smad2/3 signaling pathway. This shift suppresses T/NK-cell activity, allows tumor cells to evade immune killing, and accelerates PDAC progression. In addition, serum sCD58 emerges as a promising diagnostic and prognostic biomarker for PDAC.
Authors
- Yuze Hua
- Qiaofei Liu (ORCID: https://orcid.org/0000-0001-7148-2850)
- Jörg Kleeff (ORCID: https://orcid.org/0000-0003-3432-6669)
- Yalu Zhang (ORCID: https://orcid.org/0000-0001-5939-6685)
- Sen Yang
- Jiayi Li (ORCID: https://orcid.org/0000-0001-6888-0380)
- Ronghua Zhang (ORCID: https://orcid.org/0000-0002-4758-4061)
- Quan Liao (ORCID: https://orcid.org/0000-0001-5999-5602)
- Huaijin Zheng (ORCID: https://orcid.org/0009-0009-6425-3019)
Institutions
- University of Science and Technology of China (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
- Martin Luther University Halle-Wittenberg (DE)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1136/jitc-2025-012163
- Citations
- 2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.59