Linking Brain and Immune Transcriptomes to Gut-Derived Metabolites in Hepatic Encephalopathy: An Explorative Integrative Multi-Omics Approach
This study offers the first systems-level framework connecting gut-derived metabolites to HE through gene networks, challenging the ammonia-centric viewpoint. The predicted miRNAs and drugs offer translational potential for precision medicine in HE. Experimental validation of these targets is required to advance therapeutic strategies.
Authors
- Ali Sepehrinezhad (ORCID: https://orcid.org/0000-0002-5550-3639)
- Ali Shahbazi (ORCID: https://orcid.org/0000-0001-5222-4792)
Institutions
- Iran University of Medical Sciences (IR)
- Mashhad University of Medical Sciences (IR)
Publication Details
- Journal
- Hepatic Medicine Evidence and Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/hmer.s546200
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00