Single-Cell RNA Sequencing Reveals Cellular Heterogeneity and Microenvironmental Remodeling in Human Ureteral Scar Stricture Tissue
This study presents the first high-resolution single-cell atlas of ureteral scar stricture tissue, revealing profound cellular heterogeneity and remodeling of the immune-stromal-epithelial landscape. The findings also highlight intensified intercellular communication within the fibrotic microenvironment, offering novel insights into disease pathogenesis and potential therapeutic targets.
Authors
- Bingbing Hou (ORCID: https://orcid.org/0000-0002-8583-9133)
- Xiaobo Ding (ORCID: https://orcid.org/0009-0009-5446-527X)
- Zongyao Hao (ORCID: https://orcid.org/0000-0003-3399-3689)
- Yuehan Yang
- Jiankang Zhang (ORCID: https://orcid.org/0000-0001-6872-3342)
- Chang Yin Liang (ORCID: https://orcid.org/0000-0003-2317-1323)
- Yang Chen (ORCID: https://orcid.org/0000-0001-7661-5923)
- Meng Zhang (ORCID: https://orcid.org/0000-0003-4935-4005)
- Guoxiang Li (ORCID: https://orcid.org/0000-0002-8265-5996)
- Xudong Shen (ORCID: https://orcid.org/0000-0003-0447-2614)
- Jian Dai (ORCID: https://orcid.org/0000-0002-9435-6213)
- S Sang
- Zhengyao Song
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Lu'an First People's Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/jir.s540340
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00