Formulation and evaluation of herbal nanogel of butoconazole for vaginal infection

The present study aims to formulate butoconazole herbal nanogel as the available dosage forms of drug have low bioavailability due to its poor solubility. The herbal nanogel prepared would overcome this drawback as particle size is reduced and first pass metabolism of drug is avoided in this type of dosage form. Moreover to formulate herbal ingredients are used which will have no side effects. In this study we have prepared nanoparticles of cinnamon aldehyde extract and lemon grass oil by nanopercipitation method and incorporated them into a gel by dispersion method. F1 Formulation was found to be best one as it showed all positive results during evaluation studies. The prepared formulation were evaluated for following parameters like physical examination, particle size, viscosity, Ph, spread ability, drug content and in-vitro drug diffusion test.