The role of focal adhesion kinase in bladder cancer: translation from <i>in vitro</i> to <i>ex vivo</i> human urothelial carcinomas
To our knowledge, this is the first report demonstrating the role of FAK and its inhibition across both normal and cancerous bladder urothelial models. This study highlights the critical role of FAK in the progression of human bladder cancer and establishes a foundation for exploring FAK inhibition as a potential therapeutic approach in bladder cancer treatment.
Authors
- Gašper Grubelnik (ORCID: https://orcid.org/0000-0001-5783-3327)
- Aleksandar Janev (ORCID: https://orcid.org/0000-0001-9303-1903)
- Nataša Resnik (ORCID: https://orcid.org/0000-0002-3387-3487)
- Tomaž Smrkolj (ORCID: https://orcid.org/0000-0002-2768-6730)
- Daša Zupančič (ORCID: https://orcid.org/0000-0001-9492-5706)
- Mateja Erdani Kreft (ORCID: https://orcid.org/0000-0001-6486-165X)
- Tanja Jesenko (ORCID: https://orcid.org/0000-0001-5883-1673)
- Maruša Debeljak (ORCID: https://orcid.org/0000-0003-0446-5465)
- Maja Čemažar (ORCID: https://orcid.org/0000-0002-1418-1928)
- Maša Omerzel
- Gaja Markovic
Institutions
- University of Ljubljana (SI)
- Ljubljana University Medical Centre (SI)
- Institute of Oncology Ljubljana (SI)
Publication Details
- Journal
- Radiology and Oncology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2478/raon-2025-0052
- Citations
- 1
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.01