The neuroendocrine tumor of the ileocecal valve presented as an obstructive ileus – a case report and literature review
Neuroendocrine tumors of the ileocecal valve are rare, frequently manifesting with nonspecific symptoms that complicate early diagnosis.This report examines a 66-year-old woman with significant comorbidities, including diabetes mellitus and chronic renal failure, who presented to the emergency department with severe cramping abdominal pain, vomiting, and a mild fever.Initial imaging and laboratory tests yielded inconclusive results.However, a CT scan of the abdomen and pelvis revealed a small bowel obstruction at the ileocecal valve, caused by a tumor mass.Given the acute nature of her symptoms, the patient underwent an emergency right hemicolectomy with ileocolostomy.Histopathological analysis confirmed a 4 cm, well-differentiated grade 2 neuroendocrine tumor with lymphovascular invasion, along with metastases in 4 out of 17 examined lymph nodes.The patient had an uncomplicated postoperative course and was discharged on the tenth day in stable condition.This case highlights the need to consider neuroendocrine tumors in the differential diagnosis of bowel obstruction when imaging reveals a mass near the ileocecal region.Early detection and prompt surgical intervention are essential for optimal outcomes.Due to the rarity of neuroendocrine tumors in this anatomical location, this case provides valuable insights into the diagnostic and management complexities they pose.Continuous follow-up with a multidisciplinary team remains essential to monitor for potential recurrence or metastasis
Authors
- Josipa Flam (ORCID: https://orcid.org/0000-0003-1351-7511)
- Tomislav Madžar
- Zrinko Madžar
- Hrvoje Centner
- Marijan Tepeš (ORCID: https://orcid.org/0000-0001-7283-4344)
- Romana Marušić (ORCID: https://orcid.org/0000-0003-0392-2943)
- Mario Puljiz
- Denis Klapan
- Tomislav Jurić
- Dag Dušanić
- Vesna Čosić
- Blaženka Mikšić
- Andreja Bartulić
Institutions
- United Nations Children's Fund (US)
- University Hospital Centre Zagreb (HR)
- University of Applied Health Sciences (HR)
- Sisters of Charity Hospital (HR)
- Klinički bolnički centar Osijek (HR)
- University of Slavonski Brod (HR)
- University of Osijek (HR)
Publication Details
- Journal
- Libri Oncologici Croatian Journal of Oncology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.20471/lo.2025.53.01.06
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00