GENDER DIFFERENCES IN COMPLETE BLOOD COUNT PARAMETERS: A COMPARATIVE HEMATOLOGICAL STUDY

A comparative experimental investigation evaluated gender-based variations in complete blood count parameters among healthy adults. Recognizing known physiological nuances yet pursuing unexplored subtleties, this study aimed to quantify statistically significant differences across hematological indices in males versus females. In a sample sized via Epi Info to achieve 80 % power with α = 0.05, complete blood counts were compared, revealing that red blood cell count, hemoglobin concentration, hematocrit, and mean corpuscular volume exhibited significant gender-related disparities (p < 0.01), while platelet counts and white blood cell differentials demonstrated more modest variation (p < 0.05). Novel findings included a previously unreported elevation in mean corpuscular hemoglobin concentration among males, suggesting subtle sex-linked regulatory mechanisms in erythropoiesis. These outcomes emphasize inherent biological differences with clinical and diagnostic implications. The results support gender-specific reference ranges to refine diagnostic accuracy and improve personalized hematological assessment. Future research is encouraged to explore underlying hormonal, genetic, or environmental factors driving these distinctions.