Resting-state fMRI in Obsessive Compulsive Disorder patients compared to healthy controls

Introduction Previous resting-state fMRI studies have found hypoconnectivity between the areas underlying default mode and salience networks in OCD patients. A general dysconnectivity has been observed between the frontoparietal network and corticostriatal-thalamocortical loops in patients with OCD, We conducted a study to understand the neural correlates of OCD and its sub-types and compared them with healthy controls. As a part of the analysis of fMRI data, we also analyzed the resting state data for OCD patients and compared it to that of healthy controls. Objectives To study the neural correlates of OCD using functional MRI by comparing the resting state functional connectivity in OCD patients with healthy controls. Methods We used the resting state functional MRI data of 8 OCD patients and compared it with 10 healthy controls. The healthy controls and patients were not age—and sex-matched. The resting state fMRI data was assessed using the CONN functional connectivity toolbox, version 15.d, in MATLAB. The Regions of interest (ROIs) were mapped using the MNI coordinate system. The functional connectivity (FC) was studied with ROI-to-ROI analysis and seed-to-voxel analysis. Results 1. In ROI to ROI analysis between resting state networks, only one significant result was found when FC between all the brain networks was compared. as shown in table 1 and image 1. Table 1. Seed Target T-statistic X, Y, Z p-uncorrected