Association of Radiomic Features of ADC and IVIM Placental maps with Clinical Outcomes in Normal and Hypertensive Pregnancies

Motivation: Chronic hypertension (cHTN) is associated with adverse pregnancy outcomes. Radiomic analysis of MR images has the potential for early outcome prediction before the onset of clinical disease. Goal(s): To correlate MR radiomic features derived from diffusion-weighted imaging (DWI) with maternal condition (cHTN) and pregnancy outcomes (preeclampsia with severe features, small for gestational age). Approach: We performed ROI-based radiomic analysis on prospectively collected apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM) maps derived from the same DWI acquisition in normal and cHTN pregnancies. Results: Several radiomic features significantly differed between normal and cHTN pregnancies. Impact: Magnetic resonance imaging based radiomics of DWI data can distinguish pregnancies with normal from chronic hypertension pregnancies. Future work to correlate with pregnancy outcomes offers the potential for early risk assessment and improved obstetric management.