Prediction of Risk Stratification and Proliferation Status in Endometrioid Endometrial Adenocarcinoma based on Time-Dependent Diffusion MRI

Motivation: An accurate and non-invasive preoperative evaluation method is urgently needed to guide the surgical treatment of endometrioid endometrial adenocarcinoma Goal(s): this study aimed to apply td-dMRI-based microstructural mapping in predicting risk stratification and proliferation status of EEA , attempting to provide a potential method for non-invasive assessment of the prognosis. Approach: The td-dMRI data were acquired with pulsed gradient spin echo (PGSE) sequence, low and high frequency oscillating gradient spin echo (OGSEN1: 16.7 Hz; OGSEN2: 33.3 Hz) sequences on a 3.0 T MRI scanner. Results: The diagnostic potential of td-dMRI microstructural mapping is demonstrated to noninvasively probe pathologic characteristics in EEA in clinical setting Impact: high-risk and high-proliferation groups had smaller cell diameter derived from td-dMRI compared to low-risk and low-proliferation groups