Evaluation of 23Na signals in gynecological malignancies using 23Na MRI

Motivation: Advances in sodium (23Na) MRI technology enable non-invasive evaluation of tumor physiology by measuring tissue sodium concentrations. Goal(s): This study aimed to assess 23Na signals in endometrial and ovarian cancers to explore their potential clinical utility. Approach: Phantom experiments evaluated coil sensitivity and signal attenuation, while clinical assessments measured 23Na signals in cancerous and normal tissues to facilitate comparisons. Results: 23Na signals were significantly higher in malignant tissues, with ovarian cancer showing the highest intensities. Impact: 23Na MRI holds potential to differentiate benign from malignant lesions, improving diagnostic accuracy and understanding of disease pathophysiology.