Identification of Tumor Antigens and Immune Subtypes in Hepatocellular Carcinoma From a Multiomics Perspective
In summary, we found two potential tumor antigens, ZNF831 and SYNE1, and identified four immune subtypes of HCC with distinct molecular features. Our study provides novel insights into the development of cancer vaccine and precision medicine of immune oncology in HCC, which may benefit clinical practice in the future.
Authors
- Xuefang Chen (ORCID: https://orcid.org/0000-0003-4468-4195)
- Mingxin Pan (ORCID: https://orcid.org/0000-0002-3979-5571)
- Yuyan Xu (ORCID: https://orcid.org/0000-0003-3335-1248)
- Kaihang Zhong
- Guolin He (ORCID: https://orcid.org/0000-0001-8032-1434)
- Guoqiang Wang (ORCID: https://orcid.org/0000-0002-3372-8538)
- Cheng Zhang (ORCID: https://orcid.org/0000-0001-7665-8675)
- Chunming Wang (ORCID: https://orcid.org/0000-0001-9185-9678)
- Peng Cui (ORCID: https://orcid.org/0000-0001-8465-4164)
- Lei Cai (ORCID: https://orcid.org/0000-0003-1658-7996)
- Junming He (ORCID: https://orcid.org/0000-0003-3261-4202)
- Shunjun Fu (ORCID: https://orcid.org/0000-0001-5318-5908)
- Qingyu Xie
- Yusheng Han
- Shangli Cai
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Burning Rock Biotech (China) (CN)
- Zhujiang Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cancer Reports
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/cnr2.70300
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00