Investigating the Effects of NMDAR and LGI1 Antibodies on Absence Seizures: Insights from Genetic Absence Epilepsy Rats and Acute Pharmacological Model of Absence Seizures.
These results reveal a distinct pro-epileptogenic effect of NMDAR antibodies in both genetic and pharmacological models of absence epilepsy, while LGI1 antibodies appear to have a negligible effect. These findings suggest a specific role for NMDAR dysfunction in absence seizure pathophysiology and support further investigation into antibody-mediated seizure mechanisms.
Authors
- Canan Ulusoy (ORCID: https://orcid.org/0000-0002-5599-4917)
- Cem İ̇smail Küçükali (ORCID: https://orcid.org/0000-0001-9851-8577)
- Erdem Tüzün (ORCID: https://orcid.org/0000-0002-4483-0394)
- Hande Yüceer (ORCID: https://orcid.org/0000-0001-9027-5291)
- Nihan Çarçak (ORCID: https://orcid.org/0000-0001-6254-4319)
- Filiz Onat (ORCID: https://orcid.org/0000-0003-0680-4782)
- Elif Şanlı (ORCID: https://orcid.org/0000-0002-9593-7394)
- Şura Akat Pişkin
- Selen Çırak
- Beyzanur Yalçın
Institutions
- Acıbadem Adana Hospital (TR)
- Istanbul University (TR)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.29399/npa.29110
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00