Rates of clinical progression according to biological Alzheimer's disease stages
Cognitively unimpaired (CU) individuals in all tau-PET (positron emission tomography)-positive biological Alzheimer's disease (AD) stages were at significantly higher risk of clinical progression compared to individuals without AD. In individuals with mild cognitive impairment (MCI), only the A+T<sub>2HIGH</sub>+ stage reached a point where 50% of individuals had progressed to all-cause dementia, after 2.36 years. Biological AD staging demonstrated superior accuracy in predicting clinical progression to dementia compared to other PET biomarkers and demographic information. All tau-PET-positive individuals showed a significantly faster rate of cognitive decline than individuals without AD, with the A+T<sub>2HIGH</sub>+ stage showing the steepest rate of decline.
Authors
- Meredith N. Braskie (ORCID: https://orcid.org/0000-0002-6439-4243)
- Chris Hsiao (ORCID: https://orcid.org/0009-0009-2062-3516)
- Serge Gauthier (ORCID: https://orcid.org/0000-0003-4272-3330)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Joseph Therriault (ORCID: https://orcid.org/0000-0002-7826-4781)
- Karin L. Meeker (ORCID: https://orcid.org/0000-0002-2677-5715)
- Jaime Fernandez‐Arias
- Nesrine Rahmouni (ORCID: https://orcid.org/0009-0004-3081-8468)
- Arthur C. Macedo (ORCID: https://orcid.org/0000-0002-3957-0284)
- Tevy Chan (ORCID: https://orcid.org/0009-0001-9134-5949)
- Brandon J. Hall (ORCID: https://orcid.org/0009-0007-4578-2033)
- Seyyed Ali Hosseini (ORCID: https://orcid.org/0000-0001-7542-7541)
- Sid E. O’Bryant (ORCID: https://orcid.org/0000-0003-0582-5266)
- Stijn Servaes (ORCID: https://orcid.org/0000-0003-3565-1930)
- Robert Hopewell (ORCID: https://orcid.org/0000-0002-2478-5872)
- Yansheng Zheng
- Étienne Aumont (ORCID: https://orcid.org/0000-0002-8997-7090)
- Jean‐Paul Soucy
- Gleb Bezgin (ORCID: https://orcid.org/0000-0002-1069-9201)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Arthur W. Toga (ORCID: https://orcid.org/0000-0003-1454-8643)
- Paolo Vitali (ORCID: https://orcid.org/0000-0001-9204-2678)
- Yi‐Ting Wang (ORCID: https://orcid.org/0000-0003-2008-4435)
- Lydia Trudel (ORCID: https://orcid.org/0009-0002-5593-7717)
Institutions
- University of Southern California (US)
- University of North Texas (US)
- Montreal Neurological Institute and Hospital (CA)
- University of North Texas Health Science Center (US)
- University of Pittsburgh (US)
- Imaging, Brain, and Neuropsychiatry (FR)
- Southwestern Medical Center (US)
- Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal (CA)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70624
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Alzheimer's Association
- Fondation Brain Canada
- Weston Brain Institute
- Consortium canadien en neurodégénérescence associée au vieillissement
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé