Disease progression in bipolar disorder in relation to white matter microstructure: A comprehensive approach based on staging models
Results indicated more severe WM disruptions in patients at advanced stages compared to earlier stages of the disease. While these findings may imply changes occurring with disease progression, the cross-sectional design cannot rule out that they instead reflect stable clinical subtypes of varying severity. The results highlight the clinical relevance of WM alterations and the need for longitudinal studies to better understand the neurobiology and complexity of BD.
Authors
- Andreas Jansen (ORCID: https://orcid.org/0000-0002-3140-8207)
- Elisabeth Johanna Leehr (ORCID: https://orcid.org/0000-0002-9264-5003)
- Dominik Grotegerd (ORCID: https://orcid.org/0000-0001-8718-0128)
- Susanne L. Meinert (ORCID: https://orcid.org/0000-0003-2177-7161)
- Elisabeth Schrammen (ORCID: https://orcid.org/0000-0001-8710-1274)
- Philipp Kanske (ORCID: https://orcid.org/0000-0003-2027-8782)
- Hannah Meinert (ORCID: https://orcid.org/0000-0002-2230-0966)
- Katharina Thiel (ORCID: https://orcid.org/0000-0001-8297-1094)
- Katharina Förster (ORCID: https://orcid.org/0000-0002-3041-9246)
- Hamidreza Jamalabadi (ORCID: https://orcid.org/0000-0003-2485-2374)
- Michael Bauer (ORCID: https://orcid.org/0000-0002-2666-859X)
- Benjamin Straube (ORCID: https://orcid.org/0000-0002-9837-0944)
- Florian Thomas‐Odenthal (ORCID: https://orcid.org/0000-0003-4912-8307)
- Nina Alexander (ORCID: https://orcid.org/0009-0002-7412-0163)
- Tim Hahn (ORCID: https://orcid.org/0000-0001-6541-3795)
- Igor Nenadić (ORCID: https://orcid.org/0000-0002-0749-7473)
- Frederike Stein (ORCID: https://orcid.org/0000-0002-5052-6022)
- Eva Mennigen (ORCID: https://orcid.org/0000-0001-5099-0274)
- Paula Usemann (ORCID: https://orcid.org/0009-0005-4566-0058)
- Udo Dannlowski (ORCID: https://orcid.org/0000-0002-0623-3759)
- Tilo T. J. Kircher (ORCID: https://orcid.org/0000-0002-2514-2625)
- Andrea Pfennig (ORCID: https://orcid.org/0000-0002-3415-5583)
- Lea Teutenberg (ORCID: https://orcid.org/0009-0002-7783-8461)
- Kira Flinkenflügel (ORCID: https://orcid.org/0000-0001-7738-5429)
- Christoph Jurischka
- Julia Hubbert
Institutions
- Philipps University of Marburg (DE)
- Bielefeld University (DE)
- University of Münster (DE)
- Babeș-Bolyai University (RO)
- Center for Behavioral Brain Sciences (DE)
- University of Göttingen (DE)
- Technische Universität Dresden (DE)
- Bethel University (US)
Publication Details
- Journal
- European Psychiatry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1192/j.eurpsy.2025.10105
- Citations
- 1
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Deutsche Forschungsgemeinschaft