GLP‐1RA comparative effectiveness against dementia onset relative to other antidiabetic medications in a large, multi‐site cohort of patients with type 2 diabetes
We researched the comparative effects of diabetes medications on dementia. We studied a large, diverse observational cohort of patients with diabetes in the United States. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) may modestly reduce risk of dementia compared to dipeptidyl peptidase 4 inhibitor or sulfonylurea exposure. GLP-1RAs do not show evidence of dementia risk reduction compared to sodium-glucose cotransporter 2 inhibitors. Physicians may consider this when making prescription decisions with patients.
Authors
- Andrea E. Cassidy‐Bushrow (ORCID: https://orcid.org/0000-0001-8272-4448)
- Holly Finertie (ORCID: https://orcid.org/0000-0003-2732-2694)
- Alyce S. Adams (ORCID: https://orcid.org/0000-0002-0146-4996)
- Caryn Etsuko Shima Oshiro (ORCID: https://orcid.org/0000-0002-0802-9794)
- Andrew John Karter (ORCID: https://orcid.org/0000-0001-5527-316X)
- Patrick J. O’Connor (ORCID: https://orcid.org/0000-0002-2324-6228)
- Romain S. Neugebauer (ORCID: https://orcid.org/0000-0002-6085-4564)
- Nerissa Nance (ORCID: https://orcid.org/0000-0002-8407-2364)
- Maher Yassin
- Julie A. Schmittdiel (ORCID: https://orcid.org/0000-0001-8995-5345)
- Sharon Lin (ORCID: https://orcid.org/0000-0002-7923-3979)
- Paola Gilsanz (ORCID: https://orcid.org/0000-0002-7635-381X)
- Jaejin An
- Sarah Krahe‐Dombrowski
- Keanu Izadian
Institutions
- Geisinger Medical Center (US)
- Kaiser Permanente (US)
- Henry Ford Health System (US)
- Novo Nordisk (Denmark) (DK)
- Kaiser Foundation Hospital (US)
- Kaiser Permanente Moanalua Medical Center (US)
- Berkeley Public Health Division (US)
- Geisinger Neuroscience Institute (US)
- Hawaii Permanente Medical Group (US)
- HealthPartners (US)
- Michigan State University (US)
- University of California, Berkeley (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70621
- Citations
- 3
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.88
Funders
- Patient-Centered Outcomes Research Institute