Comparative transcriptomics of lateral hypothalamic cell types reveals conserved growth hormone-tachykinin dynamics in feeding
These findings uncover a conserved GH receptor-tachykinin LH population which may link metabolic hormone signaling to appetite control. Beyond its established long-term roles in growth and metabolism, we propose that GH exerts acute appetite-enhancing effects through activation of this neuronal pathway. Our comparative LH atlas highlights the evolutionary biology of hypothalamic appetite circuits.
Authors
- Vindhya Chaganty
- Ruey‐Kuang Cheng (ORCID: https://orcid.org/0000-0001-8208-0136)
- Marnie E. Halpern (ORCID: https://orcid.org/0000-0002-3634-9058)
- Sarah Luo (ORCID: https://orcid.org/0000-0002-4137-504X)
- Anand Kumar Andiappan (ORCID: https://orcid.org/0000-0002-8442-1544)
- Kimberle Shen
- Stephanie Ong (ORCID: https://orcid.org/0009-0002-3253-5344)
- Na Zhang (ORCID: https://orcid.org/0000-0001-9805-6026)
- Wei Leong Chew (ORCID: https://orcid.org/0000-0002-4774-7959)
- Sandra Tan
- Caroline Lei Wee (ORCID: https://orcid.org/0000-0003-4599-550X)
- Jung-Hwa Choi (ORCID: https://orcid.org/0000-0002-0591-9708)
- Valarie Yu Yan Tham
- Gaynah Javier Doblado
Institutions
- Dartmouth College (US)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-09-13
- DOI
- https://doi.org/10.1016/j.molmet.2025.102251
- Citations
- 2
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 2.59