Mismatch Repair Gene Deficiency in Ovarian Cancer: A Clinicopathological Analysis of MLH1, PMS2, MSH2, and MSH6 Mutations Across Histological Subtypes
MMR deficiency in OC is histotype-dependent, occurring exclusively in endometrioid carcinomas. While not prognostic in this cohort, dMMR screening may guide surveillance for synchronous malignancies and identify candidates for immunotherapy. Multicenter studies with expanded cohorts are needed to validate clinical utility.
Authors
- Akbar Ibrahımov (ORCID: https://orcid.org/0009-0007-8780-6400)
- Fidan Novruzova
Institutions
- Azerbaijan Medical University (AZ)
Publication Details
- Journal
- Asian Pacific Journal of Cancer Prevention
- Published
- 2025-09-01
- DOI
- https://doi.org/10.31557/apjcp.2025.26.9.3477
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00