Irisin/FNDC5 Regulates Endothelial Function to Improve Post‐Stroke‐Induced Cognitive Dysfunction by Stimulating AMPK‐eNOS Signaling
The study revealed a potential mechanism by which exercise-induced irisin secretion may attenuate PSCI. Irisin improved endothelial dysfunction and neuroinflammation, suggesting it may be a promising target for PSCI therapy.
Authors
- Ruihuan Pan (ORCID: https://orcid.org/0000-0002-4482-5448)
- Meifeng Zheng
- Shanshan Jiang (ORCID: https://orcid.org/0000-0002-0548-5364)
- Jian‐Hua Liang (ORCID: https://orcid.org/0000-0003-1309-8521)
- Suk‐Yu Yau (ORCID: https://orcid.org/0000-0002-7425-6741)
- Xiao Fu (ORCID: https://orcid.org/0000-0002-8611-891X)
- Y. Qiu (ORCID: https://orcid.org/0009-0008-0547-7808)
- Hector W. H. Tsang (ORCID: https://orcid.org/0000-0003-3003-8598)
- Huihui Guo (ORCID: https://orcid.org/0000-0002-0848-0585)
- Hsiu-Chung Ou
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Hong Kong Polytechnic University (HK)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Shaoxing No.6 People's Hospital (CN)
- Panyu District Central Hospital (CN)
- Shaoxing People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/brb3.70767
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Guangdong Provincial Hospital of Traditional Chinese Medicine
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Guangzhou University