Condensation reaction using monohydroxymethylated cardanol for cardanol–phenol bisphenol with ultra-low hormone receptor binding affinity
A novel bio-based cardanol-phenol bisphenol, analogous to bisphenols A/F, with hormone receptor binding affinity nearly three orders of magnitude lower than that of bisphenol A, was designed, synthesized, and characterized. The synthetic strategy capitalizes on the differential reactivity at the <i>ortho</i> and <i>para</i> positions of phenol, induced by the cardanol side chain.
Authors
- Zhen Huang (ORCID: https://orcid.org/0000-0002-0963-4494)
- Ling Chen (ORCID: https://orcid.org/0000-0002-6468-5729)
- Ningzhong Bao (ORCID: https://orcid.org/0000-0001-5617-2467)
- Liangyong Chu (ORCID: https://orcid.org/0000-0001-7496-4775)
- Lingjie Zhang (ORCID: https://orcid.org/0000-0002-5183-465X)
- Zezhang Zhu
- Xiaoyan Zhang (ORCID: https://orcid.org/0000-0002-8222-5320)
- Zihao Tian
Institutions
- Nanjing Tech University (CN)
- Nanjing Drum Tower Hospital (CN)
- Zhejiang University of Technology (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04913j
- Citations
- 1
- Primary Topic
- Ginkgo biloba and Cashew Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.38