Personalizing colorectal Cancer treatment: Chemotherapy drug testing with patient-derived tumor cell clusters
The PTC model for drug sensitivity testing has advantages of high success rate and rapid drug screening time. This study provides a promising tool for personalized chemotherapy sensitivity screening in patients with CRC and, after further clinical trials, may guide clinical treatment decision making.
Authors
- Shenyi Yin (ORCID: https://orcid.org/0000-0003-2731-5689)
- Ruiqiang Li (ORCID: https://orcid.org/0000-0003-4760-1535)
- Gengchen Xie
- Xiaoyuan Qiu (ORCID: https://orcid.org/0000-0003-1494-9068)
- Peng Li (ORCID: https://orcid.org/0000-0002-5235-6311)
- Leilei Yang (ORCID: https://orcid.org/0000-0002-4737-7652)
- Jiaolin Zhou (ORCID: https://orcid.org/0000-0003-2020-5161)
- Guole Lin
Institutions
- Union Hospital (HK)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Chinese PLA General Hospital (CN)
- Chinese General Hospital College of Nursing and Liberal Arts (PH)
- People's Liberation Army No. 150 Hospital (CN)
- Genex Systems (United States) (US)
- Annoroad Gene Technology (China) (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-09-13
- DOI
- https://doi.org/10.1016/j.tranon.2025.102518
- Citations
- 1
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.05