Pathophysiology of cognitive impairment in chronic kidney disease
CI in CKD results from a convergence of systemic and neural insults, modulated by resilience mechanisms and shaped by aging and comorbidities. Future research should explore interventions targeting modifiable contributors, such as vascular health, inflammation, and uremic toxicity, as well as enhancing neuroresilience to preserve cognitive function in this high-risk population.
Authors
- Lino Merlino (ORCID: https://orcid.org/0009-0001-4221-4512)
- James Tollitt (ORCID: https://orcid.org/0000-0002-9825-701X)
- Ross Dunne (ORCID: https://orcid.org/0000-0003-2046-6193)
- Philip A. Kalra (ORCID: https://orcid.org/0000-0001-7652-1572)
Institutions
- Greater Manchester Mental Health NHS Foundation Trust (GB)
- University of Manchester (GB)
- Salford Royal Hospital (GB)
Publication Details
- Journal
- Current Opinion in Nephrology & Hypertension
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1097/mnh.0000000000001117
- Citations
- 3
- Primary Topic
- Dialysis and Renal Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 4.29