Loss of Bile Salt Export Pump (Bsep/Abcb11) Ameliorates Toxin-induced Hepatic Fibrosis via Suppression of Hepatocellular Jun Amino-terminal Kinase Signaling and Hepatic Stellate Cell Activation
Loss of Bsep protects mice from toxin-induced liver fibrosis via suppression of hepatocellular pJNK signaling and attenuation of HSC activation.
Authors
- Tatjana Stojaković (ORCID: https://orcid.org/0000-0001-9909-9749)
- Philipp Königshofer (ORCID: https://orcid.org/0000-0003-1279-1148)
- Emmanuel D. Dixon (ORCID: https://orcid.org/0000-0002-4120-7441)
- Hubert Scharnagl (ORCID: https://orcid.org/0000-0002-2750-006X)
- Thierry Claudel (ORCID: https://orcid.org/0000-0002-5601-9830)
- Thomas Reiberger (ORCID: https://orcid.org/0000-0002-4590-3583)
- Veronika Mlitz (ORCID: https://orcid.org/0000-0002-1431-2270)
- Michael A Trauner (ORCID: https://orcid.org/0000-0002-1275-6425)
- Claudia Fuchs (ORCID: https://orcid.org/0000-0002-0636-1320)
Institutions
- Medical University of Graz (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-09-13
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101630
- Primary Topic
- Pediatric Hepatobiliary Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00