Co‐pathology in Alzheimer's disease and Lewy body disease and its association with neuropsychiatric symptoms
Neuropathological heterogeneity is high even in clinical stages without dementia. Neocortical but not limbic or brainstem LBD co-pathology is associated with hallucinations. LBs are associated with hallucinations independent of cognitive status. ADNC co-pathology is not associated with NPSs in LBD without dementia. LATE co-pathology is associated with increased risk of dementia but not NPS. Vascular co-pathology is associated with increased risk of delusions in ADNC.
Authors
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Renata Elaine Paraízo Leite (ORCID: https://orcid.org/0000-0002-5878-398X)
- Alberto Fernando Oliveira Justo (ORCID: https://orcid.org/0000-0001-5531-0485)
- Carlos Pasqualucci
- Paula Villela Nunes (ORCID: https://orcid.org/0000-0001-5323-2110)
- Eduardo Ferriolli (ORCID: https://orcid.org/0000-0002-5028-2451)
- Vítor Ribeiro Paes (ORCID: https://orcid.org/0000-0001-8752-5624)
- Christoph Mueller (ORCID: https://orcid.org/0000-0001-9816-1686)
- Dag Aarsland (ORCID: https://orcid.org/0000-0001-6314-216X)
- Cláudia Kimie Suemoto (ORCID: https://orcid.org/0000-0002-5942-4778)
- Lucy L. Gibson (ORCID: https://orcid.org/0000-0002-9815-3616)
Institutions
- University of British Columbia (CA)
- Universidade de São Paulo (BR)
- University of California, San Francisco (US)
- King's College London (GB)
- Stavanger University Hospital (NO)
- University Memory and Aging Center (US)
- Hospital Amaral Carvalho (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70693
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- South London and Maudsley NHS Foundation Trust
- Alzheimer's Society
- National Institute for Health and Care Research
- Department of Health and Social Care
- King's College London
- NIHR Maudsley Biomedical Research Centre